More than a mere supply of monomers: G-Actin pools regulate actin dynamics in dendritic spines
نویسنده
چکیده
Synaptic activity reshapes the morphology of dendritic spines via regulating F-actin arborization. In this issue, Lei et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201612042) reports a novel, G-actin-dependent regulation of actin polymerization within spine heads. They show that actin monomer levels are elevated in spines upon activity, with G-actin immobilized by the local enrichment of phosphatidylinositol (3,4,5)-triphosphate (PIP3) within the spine plasma membrane.
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عنوان ژورنال:
دوره 216 شماره
صفحات -
تاریخ انتشار 2017